Is honey safe for diabetics? Will honey spike blood sugar levels? 1️⃣ Does Honey Spike Blood Sugar? Yes! Although honey is a natural sweetener, it contains fructose and glucose, which can rapidly raise blood sugar levels. The glycemic index (GI) of honey is 58 (moderate), meaning it causes a blood sugar spike almost as fast as sugar (GI 60-65). Even though honey has some antioxidants and nutrients, these benefits do not outweigh the impact on blood sugar, especially for diabetics and insulin-res