Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura In acquired thrombotic thrombocytopenic purpura (TTP), an immune-mediated deficiency of the von Willebrand factor–cleaving protease ADAMTS13 allows unrestrained adhesion of von Willebrand factor multimers to platelets and microthrombosis, which result in thrombocytopenia, hemolytic anemia, and tissue ischemia. Caplacizumab, an anti–von Willebrand factor humanized, bivalent variable-domain-only immunoglobulin fragment, inhibi
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What is acquired thrombotic thrombocytopenic purpura (#aTTP)? It’s a rare #bleedingdisorder that is most common in women between the ages of 30 and 50 years old. This #InternationalTTPAwarenessDay (Sept 18) learn about this serious disease below. | Sanofi
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