The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

San Francisco 49ers quarterback Brock Purdy (shoulder) has proven his value to his team on many occasions. There aren't many ...

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

San Francisco 49ers quarterback and Iowa State alum Brock Purdy is showing promising signs after being injured on Nov. 17.

Kansas center Hunter Dickinson was ejected midway through the second half of the top-ranked Jayhawks’ game against No. 11 ...

The San Francisco 49ers are 5-6 after a brutal loss to the Green Bay Packers in Week 12. With the playoffs slipping away, ...

Kyle Shanahan was asked about 49ers quarterback Brock Purdy's injured throwing shoulder on Monday. Here's what Shanahan said ...

Brandon Allen's first start with the 49ers didn't go so well. He made some nice throws, but he fumbled twice, threw an ...