The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

San Francisco 49ers quarterback Brock Purdy suffered a shoulder injury back in Week 11 against the Seahawks and was held out ...

The San Francisco 49ers are reportedly hoping that quarterback Brock Purdy's shoulder injury isn't a long-term issue, but ...

San Francisco isn't a stranger to taking chances on former starters. The 49ers had Sam Darnold on the roster last year and he ...

After the San Francisco 49ers' crushing 38-10 defeat to the Green Bay Packers on Sunday, Eric Branch of the San Francisco ...

San Francisco 49ers quarterback and Iowa State alum Brock Purdy is showing promising signs after being injured on Nov. 17.

The 49ers were surprised about Brock Purdy's injury and the severity of it ahead of their game against the Packers in Week 12 ...

Brandon Allen's first start with the 49ers didn't go so well. He made some nice throws, but he fumbled twice, threw an ...

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game ...