Ranking all 32 teams using advanced analytics results in seven of the top 11 teams being from the AFC, while nine of the bottom 13 are also from the AFC. It's a conference of extremes, and here's how its teams stack up entering Week 13.

The Buffalo Bills may have something extra to be thankful for on Thursday. Buffalo could be a win away from a fifth straight title in the AFC East shortly after the Thanksgiving feast. The Bills can clinch the division in Week 13 if the Miami Dolphins lose to the Green Bay Packers at Lambeau Field on Thursday Night Football and Buffalo defeats the San Francisco 49ers at Highmark Stadium on Sunday Night Football.

If the Bills do clinch the AFC East on Sunday, they'd be the earliest team to win a division since the New Orleans Saints won the NFC South during Week 13 of the 2019 season. Buff

The Buffalo Bills will play the San Francisco 49ers at home at Highmark Stadium on "Sunday Night Football" in Week 13. The Bills (9-2) are looking to build on a six-game win streak, while the 49ers (5-6) have lost their last two.

See who's in and who's out for the Week 13 matchup between the Buffalo Bills and San Francisco 49ers on December 1, 2024.

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert. If they get back the right players, the Bills will be facing a much tougher game against a playoff-level team desperate to keep their hopes alive.