Release of the drug from the bone mineral matrix requires bone resorption, and reduction in bone resorption is the primary mode of action of bisphosphonates. The terminal half-life of alendronate ...

The analysis was supported by the makers of alendronate and zoledronic acid. The trials included about 7800 bisphosphonate recipients and 7500 placebo recipients: 3900 patients received zoledronic ...

This study investigated whether bisphosphonate (Alendronate,ALN) treatment could address bone deficits and arterial calcification in Mgp-null mice. Methods: Mgp-null mice were subjected to various ...

Osteoporosis, a disease that weakens your bones, is also called a “silent” disease because there are no warning signs until a ...

This literature review aimed to raise the relationship between rheumatoid arthritis and mandibular osteonecrosis associated with bisphosphonates. The articles were collected in Pubmed, Bireme, ...