The Rams have their work cut out for them in Week 3 but they have a chance to upset the 49ers if they win these 5 matchups

Just as the San Francisco 49ers won’t miss seeing Aaron Donald lining up for the Los Angeles Rams on Sunday, Sean McVay won’t miss game planning against Christian McCaffrey and Deebo Samuel. Both 49ers stars are out with injuries for this weekend’s game at SoFi Stadium,

The San Francisco 49ers have played games without Deebo Samuel Sr. in the last year and a half. And they’ve played games without Christian McCaffrey in the last year and a half. But they’ve never played a game in that span without either Samuel or McCaffrey,

Sunday's game between the Los Angeles Rams and San Francisco 49ers is a big one for both teams. The Rams are trying to avoid a dreaded 0-3 start, while the 49ers are trying to move above .500 rather than sinking to 1-2.

Just two games into the season, the Rams (0-2) are approaching desperate times as they prepare to face the San Francisco 49ers (1-1) Sunday afternoon at SoFi Stadium. The list of issues thus far for the Rams is probably as long as their injury report.

The 49ers woes in Minnesota continued last week when their former quarterback Sam Darnold torched his old squad. The offense looked like it misses Christian McCaffrey but the defense was surprisingly exposed.