Topical clindamycin is a first-line treatment for a severe type of acne that happens when bacteria clog pores and triggers ...

Clindamycin and erythromycin inhibit protein synthesis by irreversibly binding to the ribosomal 50S subunit of P. acnes (Physician's Desk Reference, 2001). Whereas erythromycin is bactericidal ...

Initially, BP/clindamycin should be used twice daily; this can be reduced to once daily if skin irritation is unacceptable. In clinical trials of mild-to-moderate acne, efficacy of once or twice ...