Release of the drug from the bone mineral matrix requires bone resorption, and reduction in bone resorption is the primary mode of action of bisphosphonates. The terminal half-life of alendronate ...

The first-line drugs for treatment of glucocorticoid-induced osteoporosis include bisphosphonates: alendronate and risedronate, while zoledronate or teriparatide should be considered as the second ...

Long-term treatment with the oral bisphosphonate alendronate increases the number of osteoclasts and can lead to formation of giant osteoclasts, according to Robert S. Weinstein of the University ...