San Francisco 49ers wide receiver Brandon Aiyuk will be the first guest to appear on his teammates' show Cleats and Convos with Deebo Samuel.

When Christian McCaffrey went down, the 49ers could take solace in the fact that they had another versatile and dynamic weapon in Deebo Samuel. For the next two games, the 49ers will be without both as Samuel reported to work with a calf strain that coach Kyle Shanahan said would likely keep him out two weeks.

Already without Christian McCaffrey, who’s on injured reserve, the 49es also won’t have Deebo Samuel for Sunday’s game against the Rams. It was announced on Monday that Samuel has a calf strain and will miss a couple of weeks.

The San Francisco 49ers loss to the Minnesota Vikings will likely be headlined by a historic connection between former Niner Sam Darnold and his new star pass catcher Justin Jefferson. After stopping the 49ers on fourth and goal at the goal line,

Fred Warner and the San Francisco 49ers couldn't get the defense stops they needed during their rough 23-17 loss to the Minnesota Vikings on Sunday.