Haute-Saône is a department in the Bourgogne-Franche-Comté region of northeastern France. Named after the river Saône, it had a populatio…Haute-Saône is a department in the Bourgogne-Franche-Comté region of northeastern France. Named after the river Saône, it had a population of 235,313 in 2019. Its prefecture is Vesoul; its sole subprefecture is Lure.