A second space age spanning omics, platforms and medicine
WEBJun 11, 2024 · The SpaceX I4 mission enabled state-of-the-art, single-cell multi-omics analysis for four astronauts, revealing that spaceflight-induced changes in gene expression, chromatin accessibility and...
Search and match across spatial omics samples at single-cell
WEB4 days ago · Here, we introduce CAST Projection, an unsupervised, label-free method to project single cells from query samples onto a reference sample toward spatially resolved single-cell multi-omics (Fig. 5a ...
Methods and applications for single-cell and spatial multi-omics
WEBMar 2, 2023 · In this Review, we highlight advances in the fast-developing field of single-cell and spatial multi-omics technologies (also known as multimodal omics approaches), and the computational...
The dawn of spatial omics | Science - AAAS
WEBJust as single-cell sequencing has revolutionized many fields of biology, spatial “omics,” in which molecular parameters are measured in situ on intact tissue samples, is set to empower a new generation of scientific discoveries.
Omics Studies of Specialized Cells and Stem Cells under …
WEB5 days ago · The primary objective of omics in space with focus on the human organism is to characterize and quantify biological factors that alter structure, morphology, function, and dynamics of human cells exposed to microgravity. This review discusses exciting data regarding genomics, transcriptomics, epigenomics, metabolomics, and proteomics of human cells and individuals in space, as well as cells ...
Search and match across spatial omics samples at single-cell
WEBA comparative analysis tool that can search, match and visualize both similarities and differences of molecular features in space across multiple samples is lacking. To address this, we introduce CAST (cross-sample alignment of spatial omics), a deep graph neural network-based method enabling spatial-to-spatial searching and matching at the ...
Challenges and considerations for single-cell and ... - Cell Press
WEBSingle-cell RNA sequencing (scRNA-seq) and spatially resolved transcriptomics (SRT) have experienced rapid development in recent years. The findings of spaceflight-based scRNA-seq and SRT investigations are likely to improve our understanding of life in space and our comprehension of gene expression in various cell systems and tissue dynamics.
Enhancing European capabilities for application of multi-omics …
WEBJul 11, 2023 · We focus on four main themes: i) continued participation in and coordination with international omics endeavors, ii) strengthening of the European space omics infrastructure including workforce and facilities, iii) capitalizing on the emerging opportunities in the commercial space sector, and iv) capitalizing on the emerging opportunities in hum...
Comprehensive Multi-omics Analysis Reveals Mitochondrial ... - Cell …
WEBNov 25, 2020 · A comprehensive multi-omics analysis from 59 astronauts and hundreds of samples flown in space provides insight into fundamental biological mechanisms affected by spaceflight and highlights mitochondrial dysregulation as a central hub for space biology.
scCross: a deep generative model for unifying single-cell multi-omics …
WEBJul 29, 2024 · scCross improves single-cell multi-omics integration over established methods. Single-cell multi-omics data has emerged as a transformative tool that comprehensively captures cellular states, offering profound …
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